Part of the Peptivitalis Compound Index.
Statements under Research findings describe published research on the molecule. They are not statements about the properties, effects or suitability of anything Peptivitalis supplies, and they are not guidance for use in humans or animals. Every finding names the model system it came from, and the limits of the evidence are stated alongside it.
MOTS-c
Identity
| CAS | 1627580-64-6 |
| Molecular weight | 2174.6 g/mol |
| Sequence | MRWQEMGYIFYPRKLR (16 residues) |
| Origin | Encoded within a short open reading frame in the mitochondrial 12S rRNA gene |
Research findings
- Described as a mitochondrial-derived peptide translated in the mitochondrion and translocating to cytoplasm and nucleus, where AMPK activation and folate one-carbon metabolism are the proposed pathway, with downstream effects on glucose uptake in skeletal muscle [1]
- Identified and characterised as a peptide encoded in mtDNA regulating insulin sensitivity and metabolic homeostasis; improved insulin sensitivity and reduced age-related insulin resistance were reported in preclinical testing [1]
- Untargeted metabolomics in preclinical models reported reductions in sphingolipid, monoacylglycerol and dicarboxylate metabolism pathways [2]
- Findings are from preclinical and cell-line models; circulating MOTS-c has been measured in human plasma, but we are not aware of any published human study of administered MOTS-c
Research focus
- Mitochondrial-derived peptide biology
- AMPK and cellular energy regulation
- Glucose metabolism and insulin sensitivity
- Exercise physiology
Availability and handling
Lyophilised powder. Store at 2–8 °C, protected from light. Specification: ≥98% by RP-HPLC; identity by mass spectrometry; water content by Karl Fischer.
Literature
- Lee C, Zeng J, Drew BG, et al. The mitochondrial-derived peptide MOTS-c promotes metabolic homeostasis and reduces obesity and insulin resistance. Cell Metab. 2015;21(3):443–54. PMCID PMC4350682
- Kim SJ, Miller B, Mehta HH, et al. The mitochondrial-derived peptide MOTS-c is a regulator of plasma metabolites and enhances insulin sensitivity. Physiol Rep. 2019;7(13):e14171. DOI 10.14814/phy2.14171 · PMCID PMC6640593
Citation note. Supplier sites cite the Lee 2015 paper with two conflicting PMIDs. Only one can be correct, so the PMCID is given — PMC4350682 resolves unambiguously.
Availability: 10 mg · SKU MS10